| Laguna Niguel to Sestu | 6,363.17 mi (10,240.54 km) |
| Laguna Niguel to Settimo Torinese | 6,019.58 mi (9,687.57 km) |
| Laguna Niguel to Seveso | 6,038.35 mi (9,717.79 km) |
| Laguna Niguel to Sezze | 6,383.67 mi (10,273.53 km) |
| Laguna Niguel to Siano | 6,474.19 mi (10,419.20 km) |
| Laguna Niguel to Siena | 6,230.48 mi (10,027.00 km) |
| Laguna Niguel to Signa | 6,198.51 mi (9,975.55 km) |
| Laguna Niguel to Silea | 6,137.46 mi (9,877.29 km) |
| Laguna Niguel to Silvi Paese | 6,360.92 mi (10,236.91 km) |
| Laguna Niguel to Sinalunga | 6,248.90 mi (10,056.63 km) |
| Laguna Niguel to Siniscola | 6,318.71 mi (10,168.97 km) |
| Laguna Niguel to Sinnai | 6,366.98 mi (10,246.67 km) |
| Laguna Niguel to Siracusa | 6,697.12 mi (10,777.97 km) |
| Laguna Niguel to Solaro | 6,038.08 mi (9,717.36 km) |
| Laguna Niguel to Soliera | 6,142.76 mi (9,885.82 km) |
