| Laguna Niguel to Sesena | 5,836.23 mi (9,392.51 km) |
| Laguna Niguel to Sestao | 5,720.60 mi (9,206.41 km) |
| Laguna Niguel to Sevilla | 5,866.77 mi (9,441.66 km) |
| Laguna Niguel to Sevilla La Nueva | 5,812.05 mi (9,353.59 km) |
| Laguna Niguel to Silla | 6,001.57 mi (9,658.59 km) |
| Laguna Niguel to Silleda | 5,540.70 mi (8,916.90 km) |
| Laguna Niguel to Sitges | 5,999.47 mi (9,655.21 km) |
| Laguna Niguel to Socuellamos | 5,909.11 mi (9,509.79 km) |
| Laguna Niguel to Soller | 6,103.53 mi (9,822.68 km) |
| Laguna Niguel to Solsona | 5,952.67 mi (9,579.89 km) |
| Laguna Niguel to Son Servera | 6,135.71 mi (9,874.47 km) |
| Laguna Niguel to Sonseca | 5,843.95 mi (9,404.92 km) |
| Laguna Niguel to Sopelana | 5,718.46 mi (9,202.97 km) |
| Laguna Niguel to Soria | 5,810.72 mi (9,351.45 km) |
| Laguna Niguel to Suances | 5,674.93 mi (9,132.92 km) |
