| Lake Shore to Southern Pines (North Carolina) | 314.26 mi (505.76 km) |
| Lake Shore to Southfield (Michigan) | 423.88 mi (682.18 km) |
| Lake Shore to Southgate (Michigan) | 412.04 mi (663.12 km) |
| Lake Shore to Southlake (Texas) | 1,226.85 mi (1,974.43 km) |
| Lake Shore to Spanaway (Washington) | 2,346.58 mi (3,776.45 km) |
| Lake Shore to Spanish Fork (Utah) | 1,860.32 mi (2,993.90 km) |
| Lake Shore to Spanish Lake (Missouri) | 736.89 mi (1,185.92 km) |
| Lake Shore to Spanish Springs (Nevada) | 2,283.80 mi (3,675.42 km) |
| Lake Shore to Sparks (Nevada) | 2,287.53 mi (3,681.43 km) |
| Lake Shore to Spartanburg (South Carolina) | 415.22 mi (668.23 km) |
| Lake Shore to Spearfish (South Dakota) | 1,448.54 mi (2,331.20 km) |
| Lake Shore to Speedway (Indiana) | 522.68 mi (841.17 km) |
| Lake Shore to Spencer (Iowa) | 1,008.43 mi (1,622.92 km) |
| Lake Shore to Spokane (Washington) | 2,112.34 mi (3,399.48 km) |
| Lake Shore to Spokane Valley (Washington) | 2,103.10 mi (3,384.61 km) |
