| Le Puy-en-Velay to Sala Consilina | 674.75 mi (1,085.90 km) |
| Le Puy-en-Velay to Salemi | 679.31 mi (1,093.25 km) |
| Le Puy-en-Velay to Salerno | 627.09 mi (1,009.20 km) |
| Le Puy-en-Velay to Salo | 325.17 mi (523.31 km) |
| Le Puy-en-Velay to Salsomaggiore Terme | 298.48 mi (480.35 km) |
| Le Puy-en-Velay to Saluzzo | 178.75 mi (287.66 km) |
| Le Puy-en-Velay to Salzano | 401.39 mi (645.98 km) |
| Le Puy-en-Velay to Samarate | 241.17 mi (388.12 km) |
| Le Puy-en-Velay to San Benedetto del Tronto | 517.18 mi (832.33 km) |
| Le Puy-en-Velay to San Biagio di Callalta | 414.64 mi (667.31 km) |
| Le Puy-en-Velay to San Bonifacio | 360.77 mi (580.60 km) |
| Le Puy-en-Velay to San Casciano in Val di Pesa | 373.07 mi (600.39 km) |
| Le Puy-en-Velay to San Cataldo | 739.11 mi (1,189.48 km) |
| Le Puy-en-Velay to San Cesareo | 499.41 mi (803.73 km) |
| Le Puy-en-Velay to San Dona di Piave | 423.26 mi (681.18 km) |
