| Le Puy-en-Velay to Settimo Torinese | 189.44 mi (304.87 km) |
| Le Puy-en-Velay to Seveso | 258.37 mi (415.81 km) |
| Le Puy-en-Velay to Sezze | 522.33 mi (840.62 km) |
| Le Puy-en-Velay to Siano | 619.72 mi (997.34 km) |
| Le Puy-en-Velay to Siena | 387.57 mi (623.73 km) |
| Le Puy-en-Velay to Signa | 366.44 mi (589.73 km) |
| Le Puy-en-Velay to Silea | 410.44 mi (660.54 km) |
| Le Puy-en-Velay to Silvi Paese | 538.11 mi (866.01 km) |
| Le Puy-en-Velay to Sinalunga | 408.97 mi (658.17 km) |
| Le Puy-en-Velay to Siniscola | 426.52 mi (686.42 km) |
| Le Puy-en-Velay to Sinnai | 480.88 mi (773.90 km) |
| Le Puy-en-Velay to Siracusa | 808.77 mi (1,301.59 km) |
| Le Puy-en-Velay to Solaro | 255.56 mi (411.28 km) |
| Le Puy-en-Velay to Soliera | 345.11 mi (555.41 km) |
| Le Puy-en-Velay to Solofra | 625.54 mi (1,006.71 km) |
