| Lecce to Santeramo in Colle | 79.78 mi (128.39 km) |
| Lecce to Santo Stefano di Magra | 497.08 mi (799.97 km) |
| Lecce to Santo Stino di Livenza | 463.45 mi (745.85 km) |
| Lecce to Sarezzo | 543.71 mi (875.02 km) |
| Lecce to Sarno | 189.04 mi (304.23 km) |
| Lecce to Saronno | 587.39 mi (945.31 km) |
| Lecce to Sarzana | 493.49 mi (794.20 km) |
| Lecce to Sassari | 504.90 mi (812.55 km) |
| Lecce to Sasso Marconi | 450.22 mi (724.55 km) |
| Lecce to Sassuolo | 474.94 mi (764.34 km) |
| Lecce to Sava | 31.77 mi (51.13 km) |
| Lecce to Saviano | 195.33 mi (314.36 km) |
| Lecce to Savigliano | 612.65 mi (985.97 km) |
| Lecce to Savignano sul Panaro | 462.25 mi (743.92 km) |
| Lecce to Savignano sul Rubicone | 392.22 mi (631.22 km) |
