| Leighton Buzzard to Sacile | 723.39 mi (1,164.18 km) |
| Leighton Buzzard to Sala Consilina | 1,108.17 mi (1,783.43 km) |
| Leighton Buzzard to Salemi | 1,172.13 mi (1,886.37 km) |
| Leighton Buzzard to Salerno | 1,065.58 mi (1,714.88 km) |
| Leighton Buzzard to Salo | 669.87 mi (1,078.05 km) |
| Leighton Buzzard to Salsomaggiore Terme | 691.03 mi (1,112.11 km) |
| Leighton Buzzard to Saluzzo | 626.00 mi (1,007.44 km) |
| Leighton Buzzard to Salzano | 728.85 mi (1,172.97 km) |
| Leighton Buzzard to Samarate | 611.01 mi (983.32 km) |
| Leighton Buzzard to San Benedetto del Tronto | 916.68 mi (1,475.25 km) |
| Leighton Buzzard to San Biagio di Callalta | 731.48 mi (1,177.20 km) |
| Leighton Buzzard to San Bonifacio | 705.52 mi (1,135.42 km) |
| Leighton Buzzard to San Casciano in Val di Pesa | 790.67 mi (1,272.45 km) |
| Leighton Buzzard to San Cataldo | 1,224.57 mi (1,970.76 km) |
| Leighton Buzzard to San Cesareo | 941.13 mi (1,514.61 km) |
