| Liberty Lake to Southern Pines (North Carolina) | 2,108.41 mi (3,393.16 km) |
| Liberty Lake to Southfield (Michigan) | 1,675.71 mi (2,696.79 km) |
| Liberty Lake to Southgate (Michigan) | 1,686.00 mi (2,713.35 km) |
| Liberty Lake to Southlake (Texas) | 1,454.22 mi (2,340.34 km) |
| Liberty Lake to Spanaway (Washington) | 251.92 mi (405.43 km) |
| Liberty Lake to Spanish Fork (Utah) | 588.48 mi (947.06 km) |
| Liberty Lake to Spanish Lake (Missouri) | 1,476.66 mi (2,376.45 km) |
| Liberty Lake to Spanish Springs (Nevada) | 568.13 mi (914.32 km) |
| Liberty Lake to Sparks (Nevada) | 574.28 mi (924.21 km) |
| Liberty Lake to Spartanburg (South Carolina) | 2,003.68 mi (3,224.61 km) |
| Liberty Lake to Spearfish (South Dakota) | 672.61 mi (1,082.47 km) |
| Liberty Lake to Speedway (Indiana) | 1,620.96 mi (2,608.68 km) |
| Liberty Lake to Spencer (Iowa) | 1,105.37 mi (1,778.91 km) |
| Liberty Lake to Spokane (Washington) | 15.33 mi (24.67 km) |
| Liberty Lake to Spokane Valley (Washington) | 6.11 mi (9.83 km) |
