| Littleton to Enterprise (Nevada) | 609.36 mi (980.66 km) |
| Littleton to Enumclaw (Washington) | 997.98 mi (1,606.09 km) |
| Littleton to Ephrata (Pennsylvania) | 1,522.67 mi (2,450.50 km) |
| Littleton to Erie (Colorado) | 31.04 mi (49.95 km) |
| Littleton to Erie (Pennsylvania) | 1,310.54 mi (2,109.11 km) |
| Littleton to Erlanger (Kentucky) | 1,090.83 mi (1,755.52 km) |
| Littleton to Escanaba (Michigan) | 1,002.29 mi (1,613.02 km) |
| Littleton to Escondido (California) | 804.33 mi (1,294.45 km) |
| Littleton to Española (New Mexico) | 254.38 mi (409.38 km) |
| Littleton to Essex (Maryland) | 1,518.22 mi (2,443.34 km) |
| Littleton to Essex Junction (Vermont) | 1,660.64 mi (2,672.54 km) |
| Littleton to Estelle (Louisiana) | 1,079.65 mi (1,737.52 km) |
| Littleton to Estero (Florida) | 1,616.26 mi (2,601.12 km) |
| Littleton to Euclid (Ohio) | 1,236.83 mi (1,990.49 km) |
| Littleton to Eufaula (Alabama) | 1,230.38 mi (1,980.10 km) |
