| Lone Tree to Southern Pines (North Carolina) | 1,425.23 mi (2,293.68 km) |
| Lone Tree to Southfield (Michigan) | 1,141.80 mi (1,837.55 km) |
| Lone Tree to Southgate (Michigan) | 1,143.78 mi (1,840.73 km) |
| Lone Tree to Southlake (Texas) | 625.25 mi (1,006.24 km) |
| Lone Tree to Spanaway (Washington) | 1,022.23 mi (1,645.12 km) |
| Lone Tree to Spanish Fork (Utah) | 361.38 mi (581.58 km) |
| Lone Tree to Spanish Lake (Missouri) | 786.37 mi (1,265.54 km) |
| Lone Tree to Spanish Springs (Nevada) | 787.06 mi (1,266.65 km) |
| Lone Tree to Sparks (Nevada) | 789.97 mi (1,271.33 km) |
| Lone Tree to Spartanburg (South Carolina) | 1,297.45 mi (2,088.04 km) |
| Lone Tree to Spearfish (South Dakota) | 346.95 mi (558.36 km) |
| Lone Tree to Speedway (Indiana) | 988.91 mi (1,591.50 km) |
| Lone Tree to Spencer (Iowa) | 562.14 mi (904.67 km) |
| Lone Tree to Spokane (Washington) | 841.36 mi (1,354.03 km) |
| Lone Tree to Spokane Valley (Washington) | 833.85 mi (1,341.95 km) |
