| Lowes Island to Southern Pines (North Carolina) | 289.28 mi (465.55 km) |
| Lowes Island to Southfield (Michigan) | 389.38 mi (626.64 km) |
| Lowes Island to Southgate (Michigan) | 376.44 mi (605.81 km) |
| Lowes Island to Southlake (Texas) | 1,180.95 mi (1,900.56 km) |
| Lowes Island to Spanaway (Washington) | 2,307.83 mi (3,714.09 km) |
| Lowes Island to Spanish Fork (Utah) | 1,816.10 mi (2,922.72 km) |
| Lowes Island to Spanish Lake (Missouri) | 690.73 mi (1,111.62 km) |
| Lowes Island to Spanish Springs (Nevada) | 2,239.96 mi (3,604.87 km) |
| Lowes Island to Sparks (Nevada) | 2,243.66 mi (3,610.83 km) |
| Lowes Island to Spartanburg (South Carolina) | 379.41 mi (610.60 km) |
| Lowes Island to Spearfish (South Dakota) | 1,407.70 mi (2,265.47 km) |
| Lowes Island to Speedway (Indiana) | 477.40 mi (768.30 km) |
| Lowes Island to Spencer (Iowa) | 967.02 mi (1,556.27 km) |
| Lowes Island to Spokane (Washington) | 2,074.03 mi (3,337.83 km) |
| Lowes Island to Spokane Valley (Washington) | 2,064.79 mi (3,322.97 km) |
