| Madrid to Sacile | 899.59 mi (1,447.75 km) |
| Madrid to Sala Consilina | 1,013.53 mi (1,631.12 km) |
| Madrid to Salemi | 901.33 mi (1,450.54 km) |
| Madrid to Salerno | 967.71 mi (1,557.38 km) |
| Madrid to Salo | 801.95 mi (1,290.61 km) |
| Madrid to Salsomaggiore Terme | 757.94 mi (1,219.79 km) |
| Madrid to Saluzzo | 639.69 mi (1,029.47 km) |
| Madrid to Salzano | 872.42 mi (1,404.03 km) |
| Madrid to Samarate | 724.75 mi (1,166.37 km) |
| Madrid to San Benedetto del Tronto | 922.41 mi (1,484.47 km) |
| Madrid to San Biagio di Callalta | 887.91 mi (1,428.95 km) |
| Madrid to San Bonifacio | 831.22 mi (1,337.72 km) |
| Madrid to San Casciano in Val di Pesa | 794.91 mi (1,279.29 km) |
| Madrid to San Cataldo | 969.97 mi (1,561.01 km) |
| Madrid to San Cesareo | 863.12 mi (1,389.06 km) |
