| Madrid to Santa Venerina | 1,026.15 mi (1,651.44 km) |
| Madrid to Santeramo in Colle | 1,071.62 mi (1,724.60 km) |
| Madrid to Santo Stefano di Magra | 741.51 mi (1,193.35 km) |
| Madrid to Santo Stino di Livenza | 902.74 mi (1,452.83 km) |
| Madrid to Sarezzo | 788.30 mi (1,268.64 km) |
| Madrid to Sarno | 959.48 mi (1,544.14 km) |
| Madrid to Saronno | 736.11 mi (1,184.66 km) |
| Madrid to Sarzana | 742.75 mi (1,195.35 km) |
| Madrid to Sassari | 643.40 mi (1,035.46 km) |
| Madrid to Sasso Marconi | 809.54 mi (1,302.82 km) |
| Madrid to Sassuolo | 790.25 mi (1,271.78 km) |
| Madrid to Sava | 1,116.31 mi (1,796.52 km) |
| Madrid to Saviano | 953.77 mi (1,534.95 km) |
| Madrid to Savigliano | 646.26 mi (1,040.06 km) |
| Madrid to Savignano sul Panaro | 800.71 mi (1,288.61 km) |
