| Madrid to Savignano sul Rubicone | 859.76 mi (1,383.66 km) |
| Madrid to Savona | 676.78 mi (1,089.18 km) |
| Madrid to Scafati | 955.06 mi (1,537.01 km) |
| Madrid to Scalea | 1,029.26 mi (1,656.43 km) |
| Madrid to Scandiano | 786.42 mi (1,265.62 km) |
| Madrid to Scandicci | 796.43 mi (1,281.73 km) |
| Madrid to Schio | 841.78 mi (1,354.72 km) |
| Madrid to Sciacca | 922.70 mi (1,484.95 km) |
| Madrid to Scicli | 1,022.81 mi (1,646.05 km) |
| Madrid to Scordia | 1,019.14 mi (1,640.15 km) |
| Madrid to Scorze | 872.90 mi (1,404.80 km) |
| Madrid to Sedico | 885.14 mi (1,424.49 km) |
| Madrid to Sedriano | 728.95 mi (1,173.13 km) |
| Madrid to Segni | 874.20 mi (1,406.89 km) |
| Madrid to Segrate | 743.69 mi (1,196.86 km) |
