| Madrid to Sangeorgiu de Mures | 1,465.51 mi (2,358.51 km) |
| Madrid to Sangeorz-Bai | 1,482.88 mi (2,386.47 km) |
| Madrid to Sannicolau Mare | 1,278.71 mi (2,057.89 km) |
| Madrid to Santana | 1,323.72 mi (2,130.31 km) |
| Madrid to Satu Mare | 1,405.69 mi (2,262.24 km) |
| Madrid to Scobinti | 1,587.55 mi (2,554.92 km) |
| Madrid to Scornicesti | 1,460.03 mi (2,349.69 km) |
| Madrid to Sebes | 1,418.51 mi (2,282.87 km) |
| Madrid to Seini | 1,423.14 mi (2,290.33 km) |
| Madrid to Sfantu-Gheorghe | 1,524.19 mi (2,452.94 km) |
| Madrid to Sibiu | 1,445.30 mi (2,325.98 km) |
| Madrid to Sighetu Marmatiei | 1,453.14 mi (2,338.60 km) |
| Madrid to Sighisoara | 1,478.48 mi (2,379.39 km) |
| Madrid to Simeria | 1,390.94 mi (2,238.50 km) |
| Madrid to Sinaia | 1,510.84 mi (2,431.47 km) |
