| Madridejos to Sestu | 673.77 mi (1,084.34 km) |
| Madridejos to Settimo Torinese | 696.65 mi (1,121.15 km) |
| Madridejos to Seveso | 771.89 mi (1,242.24 km) |
| Madridejos to Sezze | 882.18 mi (1,419.74 km) |
| Madridejos to Siano | 965.52 mi (1,553.85 km) |
| Madridejos to Siena | 813.80 mi (1,309.69 km) |
| Madridejos to Signa | 811.09 mi (1,305.32 km) |
| Madridejos to Silea | 909.77 mi (1,464.14 km) |
| Madridejos to Silvi Paese | 942.70 mi (1,517.13 km) |
| Madridejos to Sinalunga | 831.83 mi (1,338.70 km) |
| Madridejos to Siniscola | 703.51 mi (1,132.19 km) |
| Madridejos to Sinnai | 679.68 mi (1,093.85 km) |
| Madridejos to Siracusa | 1,032.36 mi (1,661.42 km) |
| Madridejos to Solaro | 768.68 mi (1,237.07 km) |
| Madridejos to Soliera | 824.21 mi (1,326.44 km) |
