| Mairena del Aljarafe to Savignano sul Rubicone | 1,070.33 mi (1,722.53 km) |
| Mairena del Aljarafe to Savona | 898.43 mi (1,445.89 km) |
| Mairena del Aljarafe to Scafati | 1,127.20 mi (1,814.06 km) |
| Mairena del Aljarafe to Scalea | 1,190.52 mi (1,915.95 km) |
| Mairena del Aljarafe to Scandiano | 1,005.01 mi (1,617.40 km) |
| Mairena del Aljarafe to Scandicci | 1,006.15 mi (1,619.24 km) |
| Mairena del Aljarafe to Schio | 1,067.57 mi (1,718.09 km) |
| Mairena del Aljarafe to Sciacca | 1,049.38 mi (1,688.81 km) |
| Mairena del Aljarafe to Scicli | 1,143.42 mi (1,840.15 km) |
| Mairena del Aljarafe to Scordia | 1,147.01 mi (1,845.93 km) |
| Mairena del Aljarafe to Scorze | 1,096.16 mi (1,764.11 km) |
| Mairena del Aljarafe to Sedico | 1,112.12 mi (1,789.79 km) |
| Mairena del Aljarafe to Sedriano | 958.68 mi (1,542.84 km) |
| Mairena del Aljarafe to Segni | 1,058.21 mi (1,703.03 km) |
| Mairena del Aljarafe to Segrate | 972.65 mi (1,565.33 km) |
