| Mairena del Aljarafe to Sestu | 831.88 mi (1,338.78 km) |
| Mairena del Aljarafe to Settimo Torinese | 896.31 mi (1,442.47 km) |
| Mairena del Aljarafe to Seveso | 971.43 mi (1,563.37 km) |
| Mairena del Aljarafe to Sezze | 1,058.59 mi (1,703.64 km) |
| Mairena del Aljarafe to Siano | 1,136.33 mi (1,828.75 km) |
| Mairena del Aljarafe to Siena | 1,002.87 mi (1,613.96 km) |
| Mairena del Aljarafe to Signa | 1,002.66 mi (1,613.63 km) |
| Mairena del Aljarafe to Silea | 1,106.80 mi (1,781.23 km) |
| Mairena del Aljarafe to Silvi Paese | 1,125.05 mi (1,810.59 km) |
| Mairena del Aljarafe to Sinalunga | 1,019.94 mi (1,641.44 km) |
| Mairena del Aljarafe to Siniscola | 874.71 mi (1,407.71 km) |
| Mairena del Aljarafe to Sinnai | 837.83 mi (1,348.35 km) |
| Mairena del Aljarafe to Siracusa | 1,172.84 mi (1,887.50 km) |
| Mairena del Aljarafe to Solaro | 968.21 mi (1,558.18 km) |
| Mairena del Aljarafe to Soliera | 1,019.74 mi (1,641.11 km) |
