| Mairena del Aljarafe to Spello | 1,060.95 mi (1,707.44 km) |
| Mairena del Aljarafe to Spilamberto | 1,018.18 mi (1,638.61 km) |
| Mairena del Aljarafe to Spilimbergo | 1,146.28 mi (1,844.76 km) |
| Mairena del Aljarafe to Spinea | 1,096.16 mi (1,764.10 km) |
| Mairena del Aljarafe to Spoleto | 1,057.48 mi (1,701.86 km) |
| Mairena del Aljarafe to Spoltore | 1,124.87 mi (1,810.30 km) |
| Mairena del Aljarafe to Spresiano | 1,108.53 mi (1,784.00 km) |
| Mairena del Aljarafe to Squinzano | 1,310.44 mi (2,108.94 km) |
| Mairena del Aljarafe to Statte | 1,266.15 mi (2,037.67 km) |
| Mairena del Aljarafe to Stezzano | 993.18 mi (1,598.36 km) |
| Mairena del Aljarafe to Strada | 1,008.12 mi (1,622.41 km) |
| Mairena del Aljarafe to Stradella | 959.10 mi (1,543.53 km) |
| Mairena del Aljarafe to Striano | 1,129.78 mi (1,818.20 km) |
| Mairena del Aljarafe to Subiaco | 1,065.61 mi (1,714.93 km) |
| Mairena del Aljarafe to Sulmona | 1,108.77 mi (1,784.39 km) |
