| Mairena del Aljarafe to Ede | 1,165.46 mi (1,875.63 km) |
| Mairena del Aljarafe to Eemnes | 1,167.36 mi (1,878.69 km) |
| Mairena del Aljarafe to Eerbeek | 1,178.11 mi (1,895.98 km) |
| Mairena del Aljarafe to Eersel | 1,117.00 mi (1,797.64 km) |
| Mairena del Aljarafe to Eijsden | 1,094.62 mi (1,761.61 km) |
| Mairena del Aljarafe to Eindhoven | 1,125.81 mi (1,811.82 km) |
| Mairena del Aljarafe to Elburg | 1,192.75 mi (1,919.55 km) |
| Mairena del Aljarafe to Emmeloord | 1,205.47 mi (1,940.02 km) |
| Mairena del Aljarafe to Emmen | 1,236.69 mi (1,990.27 km) |
| Mairena del Aljarafe to Enkhuizen | 1,194.81 mi (1,922.86 km) |
| Mairena del Aljarafe to Enschede | 1,205.02 mi (1,939.30 km) |
| Mairena del Aljarafe to Epe | 1,190.14 mi (1,915.35 km) |
| Mairena del Aljarafe to Ermelo | 1,178.68 mi (1,896.90 km) |
| Mairena del Aljarafe to Etten-Leur | 1,113.41 mi (1,791.86 km) |
| Mairena del Aljarafe to Franeker | 1,229.31 mi (1,978.38 km) |
