| Manchester to Sestu | 1,115.74 mi (1,795.61 km) |
| Manchester to Settimo Torinese | 730.65 mi (1,175.87 km) |
| Manchester to Seveso | 742.15 mi (1,194.37 km) |
| Manchester to Sezze | 1,089.02 mi (1,752.61 km) |
| Manchester to Siano | 1,177.66 mi (1,895.26 km) |
| Manchester to Siena | 935.35 mi (1,505.31 km) |
| Manchester to Signa | 902.73 mi (1,452.80 km) |
| Manchester to Silea | 843.93 mi (1,358.17 km) |
| Manchester to Silvi Paese | 1,063.87 mi (1,712.14 km) |
| Manchester to Sinalunga | 953.10 mi (1,533.87 km) |
| Manchester to Siniscola | 1,051.09 mi (1,691.56 km) |
| Manchester to Sinnai | 1,118.05 mi (1,799.33 km) |
| Manchester to Siracusa | 1,410.38 mi (2,269.79 km) |
| Manchester to Solaro | 742.05 mi (1,194.21 km) |
| Manchester to Soliera | 845.73 mi (1,361.07 km) |
