| Manchester to Shotley Bridge | 97.34 mi (156.65 km) |
| Manchester to Shrewsbury | 57.33 mi (92.26 km) |
| Manchester to Sidcup | 172.88 mi (278.22 km) |
| Manchester to Sidmouth | 197.96 mi (318.59 km) |
| Manchester to Sileby | 70.05 mi (112.73 km) |
| Manchester to Sittingbourne | 194.08 mi (312.35 km) |
| Manchester to Skegness | 109.32 mi (175.94 km) |
| Manchester to Skelmersdale | 22.34 mi (35.96 km) |
| Manchester to Skipton | 34.67 mi (55.79 km) |
| Manchester to Sleaford | 82.80 mi (133.26 km) |
| Manchester to Slough | 152.98 mi (246.20 km) |
| Manchester to Small Heath | 72.09 mi (116.02 km) |
| Manchester to Smethwick | 69.11 mi (111.22 km) |
| Manchester to Snaresbrook | 161.59 mi (260.06 km) |
| Manchester to Snodland | 186.98 mi (300.92 km) |
