| Manchester to Southwick | 105.11 mi (169.15 km) |
| Manchester to Southwick | 201.45 mi (324.20 km) |
| Manchester to Sowerby Bridge | 21.05 mi (33.87 km) |
| Manchester to Spalding | 99.09 mi (159.47 km) |
| Manchester to Spennymoor | 88.42 mi (142.29 km) |
| Manchester to Spitalfields | 163.46 mi (263.07 km) |
| Manchester to Spondon | 52.10 mi (83.85 km) |
| Manchester to Stafford | 46.76 mi (75.26 km) |
| Manchester to Staines-upon-Thames | 159.06 mi (255.98 km) |
| Manchester to Stalybridge | 8.45 mi (13.59 km) |
| Manchester to Stamford | 92.64 mi (149.09 km) |
| Manchester to Standish | 18.71 mi (30.10 km) |
| Manchester to Stanford le Hope | 176.19 mi (283.55 km) |
| Manchester to Stanley | 35.48 mi (57.10 km) |
| Manchester to Stanmore | 152.06 mi (244.71 km) |
