| Mannheim to Siegburg | 106.57 mi (171.51 km) |
| Mannheim to Siegen | 98.45 mi (158.44 km) |
| Mannheim to Sigmaringen | 102.65 mi (165.21 km) |
| Mannheim to Simbach am Inn | 223.29 mi (359.34 km) |
| Mannheim to Simmerath | 123.06 mi (198.04 km) |
| Mannheim to Sindelfingen | 58.76 mi (94.57 km) |
| Mannheim to Sinsheim | 24.95 mi (40.15 km) |
| Mannheim to Sinzheim | 51.95 mi (83.60 km) |
| Mannheim to Sinzig | 90.80 mi (146.12 km) |
| Mannheim to Soest | 144.79 mi (233.02 km) |
| Mannheim to Solingen | 131.05 mi (210.91 km) |
| Mannheim to Soltau | 248.64 mi (400.15 km) |
| Mannheim to Sommerda | 164.45 mi (264.65 km) |
| Mannheim to Sondershausen | 167.37 mi (269.35 km) |
| Mannheim to Sonneberg | 134.09 mi (215.80 km) |
