| Manzanares el Real to Spello | 863.56 mi (1,389.77 km) |
| Manzanares el Real to Spilamberto | 799.33 mi (1,286.40 km) |
| Manzanares el Real to Spilimbergo | 917.08 mi (1,475.90 km) |
| Manzanares el Real to Spinea | 870.73 mi (1,401.31 km) |
| Manzanares el Real to Spoleto | 863.04 mi (1,388.93 km) |
| Manzanares el Real to Spoltore | 936.03 mi (1,506.40 km) |
| Manzanares el Real to Spresiano | 880.75 mi (1,417.43 km) |
| Manzanares el Real to Squinzano | 1,147.00 mi (1,845.91 km) |
| Manzanares el Real to Statte | 1,101.50 mi (1,772.69 km) |
| Manzanares el Real to Stezzano | 759.69 mi (1,222.61 km) |
| Manzanares el Real to Strada | 800.81 mi (1,288.78 km) |
| Manzanares el Real to Stradella | 729.78 mi (1,174.46 km) |
| Manzanares el Real to Striano | 962.48 mi (1,548.96 km) |
| Manzanares el Real to Subiaco | 882.48 mi (1,420.21 km) |
| Manzanares el Real to Sulmona | 924.87 mi (1,488.43 km) |
