| Maryland Heights to Southern Pines (North Carolina) | 657.46 mi (1,058.08 km) |
| Maryland Heights to Southfield (Michigan) | 458.71 mi (738.22 km) |
| Maryland Heights to Southgate (Michigan) | 451.45 mi (726.54 km) |
| Maryland Heights to Southlake (Texas) | 545.97 mi (878.65 km) |
| Maryland Heights to Spanaway (Washington) | 1,703.15 mi (2,740.96 km) |
| Maryland Heights to Spanish Fork (Utah) | 1,131.21 mi (1,820.51 km) |
| Maryland Heights to Spanish Lake (Missouri) | 15.18 mi (24.42 km) |
| Maryland Heights to Spanish Springs (Nevada) | 1,557.89 mi (2,507.18 km) |
| Maryland Heights to Sparks (Nevada) | 1,561.07 mi (2,512.30 km) |
| Maryland Heights to Spartanburg (South Carolina) | 539.64 mi (868.47 km) |
| Maryland Heights to Spearfish (South Dakota) | 794.85 mi (1,279.18 km) |
| Maryland Heights to Speedway (Indiana) | 237.99 mi (383.01 km) |
| Maryland Heights to Spencer (Iowa) | 391.31 mi (629.76 km) |
| Maryland Heights to Spokane (Washington) | 1,482.07 mi (2,385.17 km) |
| Maryland Heights to Spokane Valley (Washington) | 1,473.07 mi (2,370.68 km) |
