| Mayfield Heights to Enterprise (Nevada) | 1,846.63 mi (2,971.86 km) |
| Mayfield Heights to Enumclaw (Washington) | 2,016.99 mi (3,246.04 km) |
| Mayfield Heights to Ephrata (Pennsylvania) | 290.55 mi (467.59 km) |
| Mayfield Heights to Erie (Colorado) | 1,234.41 mi (1,986.59 km) |
| Mayfield Heights to Erie (Pennsylvania) | 82.25 mi (132.37 km) |
| Mayfield Heights to Erlanger (Kentucky) | 239.29 mi (385.10 km) |
| Mayfield Heights to Escanaba (Michigan) | 405.86 mi (653.16 km) |
| Mayfield Heights to Escondido (California) | 2,024.91 mi (3,258.77 km) |
| Mayfield Heights to Española (New Mexico) | 1,374.47 mi (2,212.00 km) |
| Mayfield Heights to Essex (Maryland) | 304.65 mi (490.29 km) |
| Mayfield Heights to Essex Junction (Vermont) | 468.46 mi (753.91 km) |
| Mayfield Heights to Estelle (Louisiana) | 940.12 mi (1,512.97 km) |
| Mayfield Heights to Estero (Florida) | 1,042.79 mi (1,678.20 km) |
| Mayfield Heights to Euclid (Ohio) | 6.07 mi (9.76 km) |
| Mayfield Heights to Eufaula (Alabama) | 694.47 mi (1,117.64 km) |
