| Mechelen-aan-de-Maas to Settimo Torinese | 416.14 mi (669.71 km) |
| Mechelen-aan-de-Maas to Seveso | 402.03 mi (647.00 km) |
| Mechelen-aan-de-Maas to Sezze | 743.67 mi (1,196.83 km) |
| Mechelen-aan-de-Maas to Siano | 825.09 mi (1,327.86 km) |
| Mechelen-aan-de-Maas to Siena | 592.36 mi (953.32 km) |
| Mechelen-aan-de-Maas to Signa | 558.33 mi (898.55 km) |
| Mechelen-aan-de-Maas to Silea | 477.10 mi (767.82 km) |
| Mechelen-aan-de-Maas to Silvi Paese | 705.50 mi (1,135.39 km) |
| Mechelen-aan-de-Maas to Sinalunga | 607.29 mi (977.33 km) |
| Mechelen-aan-de-Maas to Siniscola | 745.09 mi (1,199.11 km) |
| Mechelen-aan-de-Maas to Sinnai | 825.54 mi (1,328.58 km) |
| Mechelen-aan-de-Maas to Siracusa | 1,071.54 mi (1,724.47 km) |
| Mechelen-aan-de-Maas to Solaro | 402.90 mi (648.40 km) |
| Mechelen-aan-de-Maas to Soliera | 495.26 mi (797.05 km) |
| Mechelen-aan-de-Maas to Solofra | 827.12 mi (1,331.12 km) |
