| Mechelen-aan-de-Maas to Sestao | 669.41 mi (1,077.32 km) |
| Mechelen-aan-de-Maas to Sevilla | 1,110.43 mi (1,787.06 km) |
| Mechelen-aan-de-Maas to Sevilla La Nueva | 871.32 mi (1,402.26 km) |
| Mechelen-aan-de-Maas to Silla | 856.51 mi (1,378.41 km) |
| Mechelen-aan-de-Maas to Silleda | 870.52 mi (1,400.96 km) |
| Mechelen-aan-de-Maas to Sitges | 699.65 mi (1,125.97 km) |
| Mechelen-aan-de-Maas to Socuellamos | 907.06 mi (1,459.77 km) |
| Mechelen-aan-de-Maas to Soller | 789.30 mi (1,270.26 km) |
| Mechelen-aan-de-Maas to Solsona | 652.79 mi (1,050.57 km) |
| Mechelen-aan-de-Maas to Son Servera | 794.09 mi (1,277.96 km) |
| Mechelen-aan-de-Maas to Sonseca | 908.70 mi (1,462.42 km) |
| Mechelen-aan-de-Maas to Sopelana | 664.65 mi (1,069.64 km) |
| Mechelen-aan-de-Maas to Soria | 746.17 mi (1,200.84 km) |
| Mechelen-aan-de-Maas to Suances | 693.50 mi (1,116.07 km) |
| Mechelen-aan-de-Maas to Sueca | 865.34 mi (1,392.63 km) |
