| Medford to Enterprise (Nevada) | 597.85 mi (962.15 km) |
| Medford to Enumclaw (Washington) | 338.77 mi (545.19 km) |
| Medford to Ephrata (Pennsylvania) | 2,398.17 mi (3,859.49 km) |
| Medford to Erie (Colorado) | 937.95 mi (1,509.48 km) |
| Medford to Erie (Pennsylvania) | 2,165.22 mi (3,484.59 km) |
| Medford to Erlanger (Kentucky) | 2,001.43 mi (3,221.00 km) |
| Medford to Escanaba (Michigan) | 1,776.76 mi (2,859.42 km) |
| Medford to Escondido (California) | 709.54 mi (1,141.89 km) |
| Medford to Española (New Mexico) | 997.54 mi (1,605.39 km) |
| Medford to Essex (Maryland) | 2,405.53 mi (3,871.32 km) |
| Medford to Essex Junction (Vermont) | 2,462.04 mi (3,962.27 km) |
| Medford to Estelle (Louisiana) | 2,005.55 mi (3,227.63 km) |
| Medford to Estero (Florida) | 2,554.85 mi (4,111.63 km) |
| Medford to Euclid (Ohio) | 2,103.07 mi (3,384.56 km) |
| Medford to Eufaula (Alabama) | 2,177.81 mi (3,504.85 km) |
