| Medford to Olympia Heights (Florida) | 2,656.45 mi (4,275.14 km) |
| Medford to Omaha (Nebraska) | 1,376.74 mi (2,215.64 km) |
| Medford to On Top of the World Designated Place (Florida) | 2,424.71 mi (3,902.19 km) |
| Medford to Onalaska (Wisconsin) | 1,590.03 mi (2,558.91 km) |
| Medford to Oneida (New York) | 2,364.32 mi (3,805.00 km) |
| Medford to Oneonta (New York) | 2,405.14 mi (3,870.70 km) |
| Medford to Ontario (California) | 639.91 mi (1,029.84 km) |
| Medford to Ontario (Oregon) | 318.21 mi (512.11 km) |
| Medford to Opa-locka (Florida) | 2,653.42 mi (4,270.27 km) |
| Medford to Opelika (Alabama) | 2,140.66 mi (3,445.07 km) |
| Medford to Opelousas (Louisiana) | 1,881.43 mi (3,027.87 km) |
| Medford to Orange (California) | 649.72 mi (1,045.63 km) |
| Medford to Orange (Texas) | 1,815.31 mi (2,921.46 km) |
| Medford to Orange City (Florida) | 2,481.63 mi (3,993.80 km) |
| Medford to Orangeburg (South Carolina) | 2,343.31 mi (3,771.20 km) |
