| Medford to Orangevale (California) | 266.31 mi (428.58 km) |
| Medford to Orchards (Washington) | 232.14 mi (373.60 km) |
| Medford to Orcutt (California) | 532.37 mi (856.77 km) |
| Medford to Oregon (Ohio) | 2,006.55 mi (3,229.23 km) |
| Medford to Oregon (Wisconsin) | 1,690.33 mi (2,720.32 km) |
| Medford to Oregon City (Oregon) | 208.01 mi (334.75 km) |
| Medford to Orem (Utah) | 595.26 mi (957.98 km) |
| Medford to Orinda (California) | 309.96 mi (498.84 km) |
| Medford to Orland Park (Illinois) | 1,785.44 mi (2,873.39 km) |
| Medford to Orlando (Florida) | 2,496.62 mi (4,017.93 km) |
| Medford to Ormond Beach (Florida) | 2,477.37 mi (3,986.94 km) |
| Medford to Oro Valley (Arizona) | 944.03 mi (1,519.28 km) |
| Medford to Oroville (California) | 207.29 mi (333.60 km) |
| Medford to Oshkosh (Wisconsin) | 1,719.19 mi (2,766.77 km) |
| Medford to Oskaloosa (Iowa) | 1,549.35 mi (2,493.44 km) |
