| Medford to Sanford (Maine) | 2,594.80 mi (4,175.93 km) |
| Medford to Sanford (North Carolina) | 2,368.57 mi (3,811.84 km) |
| Medford to Sanger (California) | 427.26 mi (687.61 km) |
| Medford to Santa Ana (California) | 652.63 mi (1,050.30 km) |
| Medford to Santa Barbara (California) | 572.07 mi (920.66 km) |
| Medford to Santa Clara (California) | 346.77 mi (558.07 km) |
| Medford to Santa Clara (Oregon) | 123.67 mi (199.03 km) |
| Medford to Santa Clarita (California) | 595.71 mi (958.70 km) |
| Medford to Santa Cruz (California) | 372.77 mi (599.92 km) |
| Medford to Santa Fe (New Mexico) | 1,014.09 mi (1,632.02 km) |
| Medford to Santa Fe (Texas) | 1,781.16 mi (2,866.50 km) |
| Medford to Santa Fe Springs (California) | 636.11 mi (1,023.72 km) |
| Medford to Santa Maria (California) | 527.78 mi (849.38 km) |
| Medford to Santa Monica (California) | 621.35 mi (999.97 km) |
| Medford to Santa Paula (California) | 588.34 mi (946.85 km) |
