| Medford to Scottsboro (Alabama) | 2,042.84 mi (3,287.63 km) |
| Medford to Scottsdale (Arizona) | 844.21 mi (1,358.63 km) |
| Medford to Scranton (Pennsylvania) | 2,397.05 mi (3,857.68 km) |
| Medford to Seabrook (Maryland) | 2,392.97 mi (3,851.11 km) |
| Medford to Seabrook (Texas) | 1,776.99 mi (2,859.80 km) |
| Medford to Seaford (New York) | 2,520.58 mi (4,056.48 km) |
| Medford to Seagoville (Texas) | 1,581.21 mi (2,544.72 km) |
| Medford to Seal Beach (California) | 647.32 mi (1,041.77 km) |
| Medford to Searcy (Arkansas) | 1,735.21 mi (2,792.55 km) |
| Medford to Seaside (California) | 398.68 mi (641.61 km) |
| Medford to SeaTac (Washington) | 353.92 mi (569.57 km) |
| Medford to Seattle (Washington) | 366.00 mi (589.01 km) |
| Medford to Sebastian (Florida) | 2,566.70 mi (4,130.70 km) |
| Medford to Sebring (Florida) | 2,529.81 mi (4,071.34 km) |
| Medford to Secaucus (New Jersey) | 2,489.64 mi (4,006.69 km) |
