| Medford to Southern Pines (North Carolina) | 2,365.66 mi (3,807.17 km) |
| Medford to Southfield (Michigan) | 2,001.24 mi (3,220.69 km) |
| Medford to Southgate (Michigan) | 2,008.39 mi (3,232.19 km) |
| Medford to Southlake (Texas) | 1,540.40 mi (2,479.04 km) |
| Medford to Spanaway (Washington) | 329.61 mi (530.46 km) |
| Medford to Spanish Fork (Utah) | 602.21 mi (969.16 km) |
| Medford to Spanish Lake (Missouri) | 1,720.31 mi (2,768.57 km) |
| Medford to Spanish Springs (Nevada) | 248.71 mi (400.26 km) |
| Medford to Sparks (Nevada) | 251.50 mi (404.75 km) |
| Medford to Spartanburg (South Carolina) | 2,244.35 mi (3,611.93 km) |
| Medford to Spearfish (South Dakota) | 964.79 mi (1,552.68 km) |
| Medford to Speedway (Indiana) | 1,900.26 mi (3,058.18 km) |
| Medford to Spencer (Iowa) | 1,400.32 mi (2,253.60 km) |
| Medford to Spokane (Washington) | 453.35 mi (729.60 km) |
| Medford to Spokane Valley (Washington) | 458.82 mi (738.40 km) |
