| Medford to Superior (Colorado) | 933.89 mi (1,502.95 km) |
| Medford to Superior (Wisconsin) | 1,535.34 mi (2,470.90 km) |
| Medford to Surprise (Arizona) | 822.38 mi (1,323.49 km) |
| Medford to Susanville (California) | 176.15 mi (283.48 km) |
| Medford to Sussex (Wisconsin) | 1,745.76 mi (2,809.54 km) |
| Medford to Suwanee (Georgia) | 2,162.21 mi (3,479.74 km) |
| Medford to Swansea (Illinois) | 1,736.96 mi (2,795.37 km) |
| Medford to Sweetwater (Florida) | 2,652.35 mi (4,268.54 km) |
| Medford to Sweetwater (Texas) | 1,401.75 mi (2,255.90 km) |
| Medford to Sycamore (Illinois) | 1,738.26 mi (2,797.46 km) |
| Medford to Sylacauga (Alabama) | 2,078.55 mi (3,345.11 km) |
| Medford to Sylvania (Ohio) | 1,991.71 mi (3,205.35 km) |
| Medford to Syosset (New York) | 2,516.73 mi (4,050.28 km) |
| Medford to Syracuse (New York) | 2,341.53 mi (3,768.32 km) |
| Medford to Syracuse (Utah) | 562.51 mi (905.28 km) |
