| Mendrisio to Sacile | 169.17 mi (272.25 km) |
| Mendrisio to Sala Consilina | 503.60 mi (810.46 km) |
| Mendrisio to Salemi | 589.69 mi (949.01 km) |
| Mendrisio to Salerno | 461.08 mi (742.03 km) |
| Mendrisio to Salo | 76.99 mi (123.90 km) |
| Mendrisio to Salsomaggiore Terme | 87.31 mi (140.51 km) |
| Mendrisio to Saluzzo | 111.32 mi (179.15 km) |
| Mendrisio to Salzano | 152.94 mi (246.13 km) |
| Mendrisio to Samarate | 19.78 mi (31.84 km) |
| Mendrisio to San Benedetto del Tronto | 314.71 mi (506.47 km) |
| Mendrisio to San Biagio di Callalta | 164.22 mi (264.28 km) |
| Mendrisio to San Bonifacio | 115.70 mi (186.20 km) |
| Mendrisio to San Casciano in Val di Pesa | 187.03 mi (301.00 km) |
| Mendrisio to San Cataldo | 633.78 mi (1,019.97 km) |
| Mendrisio to San Cesareo | 338.26 mi (544.37 km) |
