| Messina to Somma Lombardo | 625.48 mi (1,006.61 km) |
| Messina to Somma Vesuviana | 194.43 mi (312.90 km) |
| Messina to Sommacampagna | 553.49 mi (890.76 km) |
| Messina to Sona | 555.91 mi (894.65 km) |
| Messina to Sondrio | 622.81 mi (1,002.32 km) |
| Messina to Sora | 264.15 mi (425.10 km) |
| Messina to Sorbolo | 529.87 mi (852.74 km) |
| Messina to Soresina | 571.00 mi (918.93 km) |
| Messina to Sorisole | 602.49 mi (969.62 km) |
| Messina to Sorrento | 179.60 mi (289.04 km) |
| Messina to Sorso | 413.07 mi (664.77 km) |
| Messina to Sortino | 76.46 mi (123.04 km) |
| Messina to Soverato Marina | 63.63 mi (102.41 km) |
| Messina to Sovicille | 417.99 mi (672.69 km) |
| Messina to Spello | 364.14 mi (586.02 km) |
