| Messina to Sangeorz-Bai | 783.78 mi (1,261.37 km) |
| Messina to Sannicolau Mare | 602.06 mi (968.93 km) |
| Messina to Santana | 639.86 mi (1,029.75 km) |
| Messina to Satu Mare | 758.84 mi (1,221.23 km) |
| Messina to Scobinti | 856.16 mi (1,377.85 km) |
| Messina to Scornicesti | 640.82 mi (1,031.30 km) |
| Messina to Sebes | 675.22 mi (1,086.66 km) |
| Messina to Seini | 766.26 mi (1,233.17 km) |
| Messina to Sfantu-Gheorghe | 744.94 mi (1,198.87 km) |
| Messina to Sibiu | 685.18 mi (1,102.68 km) |
| Messina to Sighetu Marmatiei | 792.41 mi (1,275.26 km) |
| Messina to Sighisoara | 727.54 mi (1,170.86 km) |
| Messina to Simeria | 652.27 mi (1,049.73 km) |
| Messina to Sinaia | 713.03 mi (1,147.50 km) |
| Messina to Slatina | 627.57 mi (1,009.97 km) |
