| Mexborough to Southern Pines (North Carolina) | 3,849.37 mi (6,194.95 km) |
| Mexborough to Southfield (Michigan) | 3,650.81 mi (5,875.42 km) |
| Mexborough to Southgate (Michigan) | 3,661.41 mi (5,892.48 km) |
| Mexborough to Southlake (Texas) | 4,648.51 mi (7,481.05 km) |
| Mexborough to Spanaway (Washington) | 4,677.73 mi (7,528.08 km) |
| Mexborough to Spanish Fork (Utah) | 4,762.10 mi (7,663.87 km) |
| Mexborough to Spanish Lake (Missouri) | 4,089.28 mi (6,581.06 km) |
| Mexborough to Spanish Springs (Nevada) | 5,031.73 mi (8,097.79 km) |
| Mexborough to Sparks (Nevada) | 5,037.90 mi (8,107.72 km) |
| Mexborough to Spartanburg (South Carolina) | 3,961.54 mi (6,375.48 km) |
| Mexborough to Spearfish (South Dakota) | 4,275.78 mi (6,881.20 km) |
| Mexborough to Speedway (Indiana) | 3,891.14 mi (6,262.19 km) |
| Mexborough to Spencer (Iowa) | 4,051.54 mi (6,520.32 km) |
| Mexborough to Spokane (Washington) | 4,512.54 mi (7,262.24 km) |
| Mexborough to Spokane Valley (Washington) | 4,507.36 mi (7,253.90 km) |
