| Middle Valley to Orbetello | 4,922.46 mi (7,921.93 km) |
| Middle Valley to Oria | 5,274.18 mi (8,487.98 km) |
| Middle Valley to Oristano | 4,894.30 mi (7,876.61 km) |
| Middle Valley to Orta Nova | 5,158.94 mi (8,302.52 km) |
| Middle Valley to Orte | 4,972.85 mi (8,003.04 km) |
| Middle Valley to Ortona | 5,063.90 mi (8,149.56 km) |
| Middle Valley to Orvieto | 4,951.58 mi (7,968.80 km) |
| Middle Valley to Orzinuovi | 4,764.73 mi (7,668.09 km) |
| Middle Valley to Osimo | 4,982.84 mi (8,019.11 km) |
| Middle Valley to Ospitaletto | 4,765.39 mi (7,669.16 km) |
| Middle Valley to Ostuni | 5,262.82 mi (8,469.69 km) |
| Middle Valley to Ottaviano | 5,123.59 mi (8,245.63 km) |
| Middle Valley to Ovada | 4,735.31 mi (7,620.74 km) |
| Middle Valley to Ozieri | 4,889.36 mi (7,868.67 km) |
| Middle Valley to Paceco | 5,145.03 mi (8,280.13 km) |
