| Middle Valley to Sacile | 4,852.53 mi (7,809.40 km) |
| Middle Valley to Sala Consilina | 5,189.84 mi (8,352.24 km) |
| Middle Valley to Salemi | 5,162.73 mi (8,308.61 km) |
| Middle Valley to Salerno | 5,142.36 mi (8,275.83 km) |
| Middle Valley to Salo | 4,783.24 mi (7,697.89 km) |
| Middle Valley to Salsomaggiore Terme | 4,786.55 mi (7,703.20 km) |
| Middle Valley to Saluzzo | 4,685.17 mi (7,540.05 km) |
| Middle Valley to Salzano | 4,851.85 mi (7,808.30 km) |
| Middle Valley to Samarate | 4,708.75 mi (7,578.00 km) |
| Middle Valley to San Benedetto del Tronto | 5,019.48 mi (8,078.08 km) |
| Middle Valley to San Biagio di Callalta | 4,857.48 mi (7,817.35 km) |
| Middle Valley to San Bonifacio | 4,821.63 mi (7,759.66 km) |
| Middle Valley to San Casciano in Val di Pesa | 4,878.28 mi (7,850.84 km) |
| Middle Valley to San Cataldo | 5,229.48 mi (8,416.04 km) |
| Middle Valley to San Cesareo | 5,014.30 mi (8,069.74 km) |
