| Middle Valley to Santa Venerina | 5,274.04 mi (8,487.75 km) |
| Middle Valley to Santeramo in Colle | 5,225.03 mi (8,408.87 km) |
| Middle Valley to Santo Stefano di Magra | 4,806.04 mi (7,734.58 km) |
| Middle Valley to Santo Stino di Livenza | 4,868.35 mi (7,834.85 km) |
| Middle Valley to Sarezzo | 4,767.52 mi (7,672.59 km) |
| Middle Valley to Sarno | 5,130.94 mi (8,257.45 km) |
| Middle Valley to Saronno | 4,719.22 mi (7,594.85 km) |
| Middle Valley to Sarzana | 4,809.65 mi (7,740.39 km) |
| Middle Valley to Sassari | 4,864.31 mi (7,828.36 km) |
| Middle Valley to Sasso Marconi | 4,855.00 mi (7,813.37 km) |
| Middle Valley to Sassuolo | 4,829.94 mi (7,773.04 km) |
| Middle Valley to Sava | 5,275.25 mi (8,489.70 km) |
| Middle Valley to Saviano | 5,122.79 mi (8,244.33 km) |
| Middle Valley to Savigliano | 4,691.20 mi (7,549.75 km) |
| Middle Valley to Savignano sul Panaro | 4,842.87 mi (7,793.84 km) |
