| Middle Valley to Savignano sul Rubicone | 4,914.65 mi (7,909.37 km) |
| Middle Valley to Savona | 4,739.20 mi (7,627.00 km) |
| Middle Valley to Scafati | 5,129.33 mi (8,254.86 km) |
| Middle Valley to Scalea | 5,221.12 mi (8,402.57 km) |
| Middle Valley to Scandiano | 4,824.36 mi (7,764.06 km) |
| Middle Valley to Scandicci | 4,875.02 mi (7,845.58 km) |
| Middle Valley to Schio | 4,813.89 mi (7,747.21 km) |
| Middle Valley to Sciacca | 5,187.57 mi (8,348.58 km) |
| Middle Valley to Scicli | 5,289.02 mi (8,511.85 km) |
| Middle Valley to Scordia | 5,276.05 mi (8,490.97 km) |
| Middle Valley to Scorze | 4,850.17 mi (7,805.59 km) |
| Middle Valley to Sedico | 4,830.74 mi (7,774.33 km) |
| Middle Valley to Sedriano | 4,720.95 mi (7,597.64 km) |
| Middle Valley to Segni | 5,028.66 mi (8,092.84 km) |
| Middle Valley to Segrate | 4,734.68 mi (7,619.73 km) |
