| Middle Valley to Selargius | 4,943.29 mi (7,955.46 km) |
| Middle Valley to Selvazzano Dentro | 4,843.17 mi (7,794.33 km) |
| Middle Valley to Senago | 4,724.70 mi (7,603.67 km) |
| Middle Valley to Senigallia | 4,963.21 mi (7,987.51 km) |
| Middle Valley to Seravezza | 4,825.33 mi (7,765.62 km) |
| Middle Valley to Seregno | 4,725.31 mi (7,604.65 km) |
| Middle Valley to Seriate | 4,746.03 mi (7,638.00 km) |
| Middle Valley to Sermoneta | 5,032.10 mi (8,098.38 km) |
| Middle Valley to Serramanna | 4,926.35 mi (7,928.19 km) |
| Middle Valley to Serravalle Pistoiese | 4,854.62 mi (7,812.75 km) |
| Middle Valley to Sessa Aurunca | 5,085.39 mi (8,184.15 km) |
| Middle Valley to Sesto Calende | 4,698.54 mi (7,561.57 km) |
| Middle Valley to Sesto Fiorentino | 4,872.70 mi (7,841.86 km) |
| Middle Valley to Sesto San Giovanni | 4,730.61 mi (7,613.18 km) |
| Middle Valley to Sestri Levante | 4,779.78 mi (7,692.32 km) |
