| Middle Valley to Sestu | 4,938.52 mi (7,947.77 km) |
| Middle Valley to Settimo Torinese | 4,681.18 mi (7,533.63 km) |
| Middle Valley to Seveso | 4,722.88 mi (7,600.74 km) |
| Middle Valley to Sezze | 5,037.59 mi (8,107.21 km) |
| Middle Valley to Siano | 5,134.88 mi (8,263.79 km) |
| Middle Valley to Siena | 4,896.49 mi (7,880.14 km) |
| Middle Valley to Signa | 4,870.16 mi (7,837.76 km) |
| Middle Valley to Silea | 4,855.08 mi (7,813.49 km) |
| Middle Valley to Silvi Paese | 5,044.29 mi (8,118.00 km) |
| Middle Valley to Sinalunga | 4,917.45 mi (7,913.87 km) |
| Middle Valley to Siniscola | 4,921.07 mi (7,919.69 km) |
| Middle Valley to Sinnai | 4,943.52 mi (7,955.82 km) |
| Middle Valley to Siracusa | 5,304.93 mi (8,537.46 km) |
| Middle Valley to Solaro | 4,721.56 mi (7,598.61 km) |
| Middle Valley to Soliera | 4,829.40 mi (7,772.16 km) |
