| Middle Valley to Spello | 4,966.10 mi (7,992.16 km) |
| Middle Valley to Spilamberto | 4,840.42 mi (7,789.91 km) |
| Middle Valley to Spilimbergo | 4,862.71 mi (7,825.78 km) |
| Middle Valley to Spinea | 4,855.09 mi (7,813.51 km) |
| Middle Valley to Spoleto | 4,975.09 mi (8,006.63 km) |
| Middle Valley to Spoltore | 5,048.81 mi (8,125.28 km) |
| Middle Valley to Spresiano | 4,848.62 mi (7,803.10 km) |
| Middle Valley to Squinzano | 5,294.77 mi (8,521.10 km) |
| Middle Valley to Statte | 5,252.87 mi (8,453.67 km) |
| Middle Valley to Stezzano | 4,744.43 mi (7,635.42 km) |
| Middle Valley to Strada | 4,886.51 mi (7,864.08 km) |
| Middle Valley to Stradella | 4,748.49 mi (7,641.95 km) |
| Middle Valley to Striano | 5,128.75 mi (8,253.93 km) |
| Middle Valley to Subiaco | 5,023.11 mi (8,083.91 km) |
| Middle Valley to Sulmona | 5,054.73 mi (8,134.80 km) |
