| Middleburg to Enterprise (Nevada) | 1,963.90 mi (3,160.58 km) |
| Middleburg to Enumclaw (Washington) | 2,430.64 mi (3,911.74 km) |
| Middleburg to Ephrata (Pennsylvania) | 770.56 mi (1,240.10 km) |
| Middleburg to Erie (Colorado) | 1,473.46 mi (2,371.31 km) |
| Middleburg to Erie (Pennsylvania) | 839.88 mi (1,351.65 km) |
| Middleburg to Erlanger (Kentucky) | 637.62 mi (1,026.15 km) |
| Middleburg to Escanaba (Michigan) | 1,120.24 mi (1,802.85 km) |
| Middleburg to Escondido (California) | 2,071.24 mi (3,333.34 km) |
| Middleburg to Española (New Mexico) | 1,454.81 mi (2,341.29 km) |
| Middleburg to Essex (Maryland) | 710.08 mi (1,142.77 km) |
| Middleburg to Essex Junction (Vermont) | 1,106.92 mi (1,781.42 km) |
| Middleburg to Estelle (Louisiana) | 491.08 mi (790.32 km) |
| Middleburg to Estero (Florida) | 250.38 mi (402.95 km) |
| Middleburg to Euclid (Ohio) | 797.63 mi (1,283.66 km) |
| Middleburg to Eufaula (Alabama) | 231.42 mi (372.44 km) |
