| Middleburg to Southern Pines (North Carolina) | 383.84 mi (617.73 km) |
| Middleburg to Southfield (Michigan) | 861.87 mi (1,387.05 km) |
| Middleburg to Southgate (Michigan) | 842.91 mi (1,356.54 km) |
| Middleburg to Southlake (Texas) | 919.56 mi (1,479.89 km) |
| Middleburg to Spanaway (Washington) | 2,448.60 mi (3,940.64 km) |
| Middleburg to Spanish Fork (Utah) | 1,808.68 mi (2,910.79 km) |
| Middleburg to Spanish Lake (Missouri) | 766.48 mi (1,233.53 km) |
| Middleburg to Spanish Springs (Nevada) | 2,223.55 mi (3,578.45 km) |
| Middleburg to Sparks (Nevada) | 2,225.48 mi (3,581.56 km) |
| Middleburg to Spartanburg (South Carolina) | 338.15 mi (544.19 km) |
| Middleburg to Spearfish (South Dakota) | 1,555.54 mi (2,503.39 km) |
| Middleburg to Speedway (Indiana) | 716.58 mi (1,153.23 km) |
| Middleburg to Spencer (Iowa) | 1,162.79 mi (1,871.33 km) |
| Middleburg to Spokane (Washington) | 2,236.93 mi (3,599.99 km) |
| Middleburg to Spokane Valley (Washington) | 2,228.15 mi (3,585.87 km) |
