| Middleburg to Storm Lake (Iowa) | 1,139.21 mi (1,833.38 km) |
| Middleburg to Storrs (Connecticut) | 973.96 mi (1,567.43 km) |
| Middleburg to Stoughton (Wisconsin) | 977.06 mi (1,572.43 km) |
| Middleburg to Stow (Ohio) | 769.20 mi (1,237.90 km) |
| Middleburg to Streamwood (Illinois) | 897.70 mi (1,444.72 km) |
| Middleburg to Streator (Illinois) | 857.77 mi (1,380.45 km) |
| Middleburg to Streetsboro (Ohio) | 773.74 mi (1,245.21 km) |
| Middleburg to Strongsville (Ohio) | 778.18 mi (1,252.36 km) |
| Middleburg to Stuart (Florida) | 221.32 mi (356.19 km) |
| Middleburg to Stuarts Draft (Virginia) | 574.42 mi (924.43 km) |
| Middleburg to Sturgis (Michigan) | 835.07 mi (1,343.92 km) |
| Middleburg to Suamico (Wisconsin) | 1,062.33 mi (1,709.66 km) |
| Middleburg to Sudley (Virginia) | 653.60 mi (1,051.87 km) |
| Middleburg to Suffern (New York) | 879.11 mi (1,414.79 km) |
| Middleburg to Suffolk (Virginia) | 550.19 mi (885.44 km) |
